Lou Gehrig’s disease, for short crossword clue
74 Down · WSJ Crossword, October 30, 2026 · 3 letters
Explanation
The answer to “Lou Gehrig’s disease, for short” is ALS. It appears as 74 Down in the Wall Street Journal crossword of October 30, 2026, a Friday puzzle titled “Finding the Sweet Spot” by Joseph Gangi, and it fills 3 squares running top to bottom from row 12, column 13 of the 21×21 grid.
The shortening cue in the clue tells you to expect an abbreviation or initials rather than a full word. The entry begins with A and ends with S, and contains 1 vowel and 2 consonants. If you are working from the crossings, two or three confirmed letters from the Across entries should be enough to lock it in. Friday puzzles are the Journal’s contest crosswords with a hidden meta answer, so expect the rest of this grid to be pitched at the same level.
Past appearances
Clues in other WSJ puzzles with the answer ALS:
- Green, Gore and moreJul 10, 2026