Retinoid target crossword clue
119 Down · WSJ Crossword, June 27, 2026 · 4 letters
Explanation
The answer to “Retinoid target” is ACNE. It appears as 119 Down in the Wall Street Journal crossword of June 27, 2026, a Saturday puzzle titled “Happy Birthday, USA!” by Randolph Ross, and it fills 4 squares running top to bottom from row 18, column 17 of the 21×21 grid.
The clue is a straightforward definition, so the answer is a direct synonym or a factual match for the words as written. The entry begins with A and ends with E, and contains 2 vowels and 2 consonants. If you are working from the crossings, two or three confirmed letters from the Across entries should be enough to lock it in. This weekend puzzle uses the largest grid of the week, so expect the rest of this grid to be pitched at the same level.
Past appearances
ACNE has not appeared as an answer in any other WSJ puzzle in our index, which runs from May 2026 onward. It will be listed here the next time it turns up.